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KMID : 1007520130220020471
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Food Science and Biotechnology
2013 Volume.22 No. 2 p.471 ~ p.476
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Antithrombotic Potential of Extracts from Abalone, Haliotis Discus Hannai Ino: In vitro and Animal Studies
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Li Jinglei
Tong Tao
Ko Du-Ock
Kang Seong-Gook
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Abstract
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To screen the more promising antithrombotic abalone extracts, the in vitro antithrombotic activity of 6 abalone (Haliotis Discus Hannai Ino) extracts was examined in this study. Results of in vitro studies indicated that water extract of abalone viscera (WEV) presented significant longer prothrombin time (PT), partial thromboplasmatin time (APTT), and thrombin time (TT) than other abalone extracts. In addition, the platelet aggregation process was inhibited by WEV as well. The antithrombotic potential of WEV was further investigated in animal studies which revealed that WEV prolonged tail bleeding time, APTT but not PT and TT and showed no effect on the platelet aggregation and platelet number. The WEV treated rats presented lower cholesterol and triglyceride level than the control group although the difference was not statistically significant. Results of this study indicate the antithrombotic activity of abalone extracts, especially WEV, and may contribute to the further study in this field.
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KEYWORD
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antithrombotic, abalone, prothrombin time, partial thromboplasmatin time, thrombin time
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